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  ...one most immersed in matter and most opposite to ideality and excellence. Its utility lies in the warning it gives: in trying to escape pain we escape destruction. That we desire to escape pain is certain; its very definition can hardly go beyond the statement that pain is that element of feeling which we seek to abolish on account of its intrinsic quality. That this desire, however, should know how to initiate remedial action is a notion contrary to experience and in itself unthinkable. If pain could have cured us we should long ago have been saved.   The bitterest quintessence of pain is its helplessness, and our incapacity to abolish it. The most intolerable torments are those we feel gaining upon us, intensifying and prolonging themselves indefinitely. This baffling quality, so conspicuous in extreme agony, is present in all pain and is perhaps its essence. If we sought to describe by a circumlocution what is of course a primary sensation, we might scarcely do better than to say that pain is consciousness at once intense and empty,...   Santayana, George

Excerpt from The Life of Reason · This quote is about pain · Search on Google Books to find all references and sources for this quotation.

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